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Disaccharides Definition

Disaccharides [Greek di = two; sacchar = sugar] are sugars composed of 2 monosaccharides (Chart 1). Disaccharides, along with monosaccharides, are called simple carbohydrates.

Three Common Disaccharides

The three most common disaccharides in foods are sucrose, lactose and maltose.

A Typical Disaccharide Structure

A disaccharide molecule is formed by 2 monosaccharides, joined by a glycosidic bond (Picture 1). The type of a glycosidic bond can determine the properties of certain disaccharides. For example, sucrose, isomaltulose and trehalulose are all composed of glucose and fructose, which are linked by different types of glycosidic bonds.

A disaccharide picture

Picture 1. A disaccharide sucrose composed of
monosaccharides glucose and fructose

Disaccharides Examples

Chart 1. Disaccharides list, calorie value, food sources

DISACCHARIDE STRUCTURE ENZYME required for digestion Kcal/g FOODS high in disaccharides
Sucrose (saccharose, table sugar) Glucose + fructose Sucrase 3.9 Table sugar, molasses, maple syrup, fondant, cakes, candies, chocolate, ice cream, fruits, honey
Lactose (milk sugar) Glucose + galactose Lactase 3.9 Milk, ice cream, infant formula, milk chocolate, milk candies, certain pills
Maltose (malt sugar) Glucose + glucose Maltase, isomaltase 4 Spelt, kamut, sweet potatoes, barley malt syrup, high maltose corn syrup (HMCS), beer, or produced from corn
Isomaltose Glucose + glucose Isomaltase, maltase <2 Produced during digestion of starch (bread, potatoes, rice…), or artificially produced
Isomaltulose Glucose + fructose Isomaltase 4 Sugar cane syrup, honey, or artificially produced
Trehalose Glucose + glucose Trehalase 4 Mushrooms, honey, seafood, wine, or artificially produced
Trehalulose Glucose + fructose Isomaltase 4 Artificially produced from sucrose


Disaccharides are an energy source; most of them provide about 4 Calories (kilocalories) per gram, just like other carbohydrates. Disaccharides are non-essential nutrients, which means they are not necessary for health or life of human beings.

Digestion and Absorption

In order to be absorbed, disaccharides need to be digested, that is broken down, by intestinal enzymes into simple sugars (monosaccharides), which are then absorbed in the small intestine.

Disaccharide Intolerance

Disaccharide intolerance refers to gastrointestinal symptoms (diarrhea, bloating) caused by poor digestion of disaccharides due to lack of respected intestinal enzymes. Lactose intolerance is common, but intolerances to other disaccharides are rare.

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3 Responses to "Disaccharides"

  1. Richard Schatzel says:

    I am 64 and I have some sort of carbohydrate intolerance; from my reading it could be Disaccharide Intolerance.
    Question: what are treatment for this disease?

    I have a thyroid condition: hypothyroidism, which I take synthroid: 0.112MG x2 =0.224MG every morning with a glass of water on an empty stomach.

    I do get a swelling and bloating of body, and a weight gain that I cannot control.

    Please tell me what else I can do for this condition, besides dying..?

  2. Babu Ramalingaiah says:

    Hi Mr.Richard,
    U have the symptoms of Hypothyroidism. Excess weight gain, poor appetite, puffiness, intolerance to cold, lethargy, constipation, hair loss, dry skin, these are all symptoms of Hypothyroidism. It would be helpful to get ur thyroid hormone levels checked to see whether they are in the normal range and might need dose to be increased. U don’t have to die, there are things u can do staying alive.

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