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What is trehalulose?

Trehalulose is an artificial sugar, a disaccharide composed of glucose and fructose joined by an alpha (1-1) glycosidic bond [1].

Trehalulose Structure

Trehalulose structure

Picture 1. Trehalulose structural formula

Nutrition Facts

  • Calories per gram = 4 [8-p.16]
  • Sweetness relative to sucrose = 60% [1]
  • Net carbohydrates = 100%

Trehalulose Sources

Trehalulose is produced during production of isomaltulose from sucrose [1].

Trehalulose Digestion

In the small intestinal lining, the enzyme isomaltase breaks trehalulose to glucose and fructose, which are then absorbed in the small intestine [1].

Trehalulose and Dental Caries

Trehalulose has a low potency to cause dental caries [1,2,3].

Who can benefit from avoiding trehalulose?

Individuals with glucose-galactose malabsorption [6] and GLUT-1 deficiency syndrome [7] can have trouble digesting trehalulose. Individuals with hereditary fructose intolerance (HFI) cannot metabolize fructose, so they should avoid trehalulose, which contains fructose.

Trehalulose and Cooking

  • Trehalulose is a reducing sugar [4].
  • Trehalulose is highly soluble in water [5].

  1. Hamada S, 2002, Role of sweeteners in the etiology and prevention of dental caries  IUPAC
  2. Ravaud S et al, 2005, Expression, purification, crystallization and preliminary X-ray crystallographic studies of the trehalulose synthase MutB from Pseudomonas mesoacidophila MX-45  PubMed Central
  3. Thaweboon B et al, 2011, Fermentation of various sugars and sugar substitutes by oral microorganisms  Asian Pacific Journal of Tropic Biomedicine
  4. Gamble GR, 2001, The heat induced degradation of melezitose and trehalulose  International Cotton Advisory Committee
  5. 1993, Process for preparing trehalulose and isomaltulose  Patent Genius
  6. Glucose-galactose malabsorption  Genetics Home Reference
  7. GLUT1 deficiency syndrome  Genetics Home Reference
  8. Rauter AP et al, 2010, Carbohydrates in Sustainable Development I

7 Responses to "Trehalulose"

  1. Caroline Panton says:

    Is there any evidence that Trehalose can benefit Cerebella Ataxia of unknown origin or idiopathic?

    • Jan Modric says:

      Mind you, this article is about trehalulose. Trehalose is here. There have been various laboratory and animal studies done about trehalose and cerebellar ataxia, but I’m not aware of any human studies.

  2. Neera says:

    is trehalulose acarcinogenic? can you give a reference to that?

  3. Michael Easson says:

    This is the incorrect structure for trehalulose. It is not a hydrogen at the anomeric carbon but a hydroxyl

  4. Michael Easson says:

    Sorry, what do you mean yes that’s to correct?

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