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Chlorogenic Acid

What is chlorogenic acid?

Chlorogenic acids are a group of organic acids found mainly in green coffee beans and in coffee. They are nonessential nutrients.

The term chloro in Greek means green (from green coffee beans) and is not related to chlorine.

Chlorogenic Acid Supplements

Nonprescription (over-the-counter) chlorogenic acid supplements or green coffee extracts are available.

Chlorogenic Acid Health Benefits

Chlorogenic acid is POSSIBLY EFFECTIVE in decreasing high blood pressure slightly [2].

There is INSUFFICIENT EVIDENCE about the effectiveness of chlorogenic acid supplements or green coffee beans extracts in the prevention or treatment of Alzheimer’s disease, diabetes mellitus type 2, high blood pressure [2] and infections [3], or in promoting weight loss [1,4].

Chlorogenic Acid Safety: Side Effects, Toxicity

Oral chlorogenic acid supplements or green coffee extracts are POSSIBLY SAFE for most people [1].

Not enough is known about the safety of green coffee extract supplements during pregnancy and breastfeeding, so women in these periods should avoid them [1].

Who else may need to avoid the green coffee extract supplements?

People with the following conditions may need to avoid green coffee supplements (which contain caffeine) [1]:

  • Anxiety disorders
  • Bleeding disorders
  • Diabetes mellitus
  • Glaucoma
  • High blood pressure
  • Irritable bowel syndrome (IBS)

Chlorogenic Acid-Nutrient Interactions

Chlorogenic acid may decrease the absorption of glucose [5], but the importance of this effect is not known.

  1. Green beans  WebMD
  2. Onakpoya IJ et al, 2015, The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials  PubMed
  3. Almeida AA et al, 2006, Antibacterial activity of coffee extracts and selected coffee chemical compounds against enterobacteria  PubMed
  4. Onakpoya I et al, 2011, The Use of Green Coffee Extract as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials  PubMed Central
  5. Thom E, 2007, The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people  PubMed

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